Device policies: only managed or compliant devices get access.
Enable and review logs and alerts.
Backup: back up Microsoft 365 data separately if needed, as responsibility is set out in the contract.
Mind the licences
Some functions, such as conditional access or advanced protection, depend on the licence tier. Check which functions your plan includes before planning. For small environments the security defaults offer a solid start.
Check instead of assume
A configuration review shows where your tenant deviates from recommendations. That is cheaper than the consequences of a taken-over mailbox.
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Frequently asked questions
How do you secure Microsoft 365?
With MFA for all accounts, legacy authentication disabled, few administrators, email protection, device policies and logging.
What is legacy authentication?
Older sign-in methods without MFA support that attackers can use to bypass multi-factor sign-in.
Is Microsoft 365 secure after setup?
Not automatically. Default settings are a start; a review and hardening of the configuration is advisable.